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AVP does not stimulate POMC transcription either by itself or in synergism with CRH (69)
This implies that NRF2 can engage in antioxidant and detoxification reactions for an extended period, providing sustained cellular protection
Participants were initially split into an intervention group of combined 20 mg lidocaine and 1000 g B12 delivered locally by subcutaneous injection once a day whilst a control group received 1000 g B12 plus 20 mg lidocaine IM injection once a day
These findings underscore the crucial role of glucose transport and metabolism in dopaminergic cell death and the development of PD
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